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Thomas R. Kleyman, MD
Thomas R. Kleyman, MD, is a Professor of Medicine, Cell Biology and
Physiology, and Pharmacology, and Chief of the Renal-Electrolyte
Division at the University of Pittsburgh. He received his medical degree
from Washington University in St. Louis, and trained in Internal
Medicine and Nephrology at Columbia-Presbyterian Medical Center in New
York. His postdoctoral training in transport physiology and membrane
biochemistry was at Columbia University. He previously served on the
faculty of Columbia University and the faculty of University of
Pennsylvania.
Dr. Kleyman served as an Associate Editor of the American Journal of
Physiology: Renal Physiology before assuming the position of its
Editor-in-Chief in July of 2007. He was a member of the editorial board of
the Journal of Biological Chemistry, and is currently a member of the
editorial board of the Journal of Clinical Investigation. Dr. Kleyman has
served on several national peer review groups and is currently a member of
an NIH study section. Within the American Physiological Society, he served
as a member of the Joint Programming Committee and as Chair of the
Epithelial Transport Group. Within the American Heart Association, Dr.
Kleyman served as chair of the research committee of the
Pennsylvania-Delaware Affiliate, chair of the peer review steering committee
of the Mid-Atlantic consortium, member of National Research Committee, and
member of the Council on the Kidney in Cardiovascular Disease. Dr. Kleyman
is a member of numerous societies in addition to the APS and AHA, including
the American Society for Clinical Investigation, the Association of American
Physicians, and the American Society of Nephrology.
Dr. Kleyman’s research is concentrated on epithelial ion channels. Recent
work has focused on studies of the structure of the epithelial sodium
channel (ENaC), on identifying key sites within ENaC’s extracellular domains
that modulate channel gating, on the processing of these channels within the
biosynthetic pathway, and on their regulation by proteases. He is also
studying the regulation of ENaCs and maxi K+ channels by
mechanical forces.
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