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Handbooks of Physiology
 Comprehensive
and authoritative, this series is essential to the library of every
physiologist, as well as scientists and clinicians in related fields. The
Handbook of Physiology contains the most significant research
results presented in lucid and cohesive chapters that inform you not only
of current directions, but of future trends. With their extensive
bibliographic references and detailed indexes these volumes are
indispensable. But it is their content that places them in the highest
realm of academic achievement. By drawing together hard-won knowledge, the
Handbook will make possible the discoveries of tomorrow.
The American Physiological Society has enlisted the cooperation of
physiological scientists all over the world for this series, which
provides a comprehensive but critical presentation of the state of
knowledge in the various fields of functional biology. All books are 8
1/2" x 11" page size, on fine-quality paper with high-resolution
halftones, and indexed.
- Handbook of Physiology
Section 1: The Nervous System
- Volume I, Parts 1 & 2: Cellular Biology of Neurons
Volume IV: Intrinsic Regulatory Systems of the Brain
Volume V, Parts 1 & 2: Higher Functions of the Brain
Section 2: The Cardiovascular System
- Volume I: The Heart
- Volume II: Vascular Smooth Muscle
- Volume IV, Parts 1 & 2: Microcirculation
Microcirculation, 2nd
Edition (Published August 2008)
Section 3: The Respiratory System
- Volume II, Parts 1 & 2: Control of Breathing
- Volume III, Parts 1 & 2: Mechanics of Breathing
- Volume IV: Gas Exchange
Section 4: Environmental Physiology
Section 5: Adipose Tissue (out of print)
Section 6: The Gastrointestinal System
- Volume I, Parts 1 & 2: Motility and Circulation
- Volume II: Neural and Endocrine Biology
- Volume III: Salivary, Gastric, Pancreatic, and
Hepatobiliary Secretion
- Volume IV: Intestinal Absorption and Secretion
Section 7: The Endocrine System
- Volume I: Cellular Endocrinology
- Volume II: The Endocrine Pancreas and Regulation of
Metabolism
- Volume III: Endocrine Regulation of Water and
Electrolyte Balance
- Volume IV: Coping with the Environment: Neural and
Endocrine Mechanisms
- Volume V: Hormonal Control of Growth
Section 8: Renal Physiology
Section 9: Reactions to Environmental Agents
Section 10: Skeletal Muscle
Section 11: Aging
Section 12: Exercise: Regulation and Integration of
Multiple Systems
Section 13: Comparative Physiology
Section 14: Cell Physiology
A spectrum of physiological knowledge and concepts
Section 1:
The Nervous System
Edited by John M. Brookhart and Vernon B. Mountcastle
Volume I, Parts 1 and 2
Cellular Biology of Neurons
Edited by Eric R. Kandel
This volume provides a systematic introduction to the functioning of
nerve cells. Advances covered here mark the beginning of an innovative
period of research on the cell and on the molecular biology of individual
neurons and interconnected groups of cells.
1977, 1,238 pp.; 570 illus., ISBN 019-520658-4
$194.25 $95.00, APS Member price:
$126.25 $65.00
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Volume IV
Intrinsic Regulatory Systems of the Brain
Edited by Floyd E. Bloom
Volume IV proceeds from studies of synaptic transmitter mechanisms in the
central and peripheral nervous systems to studies of specific chemically
defined anatomic systems that incorporate these mechanisms and divergent
structures into a regulatory ensemble process.
The Medical Journal of Australia states, "This book and others in
this series will be a place - the place - to start a reference volume of
formidable proportions. It provides as up-to-date an account of modern,
integrative neurophysiology as could reasonable be sought, and will take the
serious student to the forefront of knowledge."
1986, 850 pp.; 371 illus., ISBN 019-520661-4
$270.95 $135.00, APS Member price:
$176.25 $90.00
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Volume V, Parts 1 and 2
Higher Functions of the Brain
Edited by Fred Plum
Volume V reviews the mechanisms underlying psychology and behavior in
animals and humans, and examines the field comprehensively from a
physiological standpoint. Recent extraordinary advances in understanding the
physiology of mammalian behavior and the mechanisms by which disease or
damage in the human brain affects the highest intellectual and behavioral
facilities are covered here.
1987, 964 pp.; 367 illus., ISBN 019-520662-2
$341.25 $170.00, APS Member price:
$222.00 $110.00
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Section 2:
The Cardiovascular System
Volume I
The Heart
Edited by Ernest Page, Harry A. Fozzard,
and R. John Solaro
Volume I provides authoritative, well-documented and critical overviews
of cardiac structure and function. This book is an exceptionally valuable
reference for the cardiovascular scientist, teacher, or clinical
investigator.
New England Journal of Medicine states, "This book will be a most
valuable reference for the cardiovascular scientist and teacher and for the
clinical investigator. It will also make rewarding reading for the advanced
student of cardiovascular physiology."
2000, 1,000 pp.; 500 illus., ISBN 019-509886-2
$198.95 $100.00, APS Member price:
$129.50 $65.00
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Volume II
Vascular Smooth Muscle
Edited by David F. Bohr, Andrew P. Somlyo,
and Harvey V. Sparks, Jr.
A comprehensive review of the structure, chemistry and function of
vascular smooth muscle, this volume reflects the extensive research by
cardiovascular physiologists on the contractile system in the blood vessel
wall.
Practical Cardiology states, "Serious students will welcome this
volume because of the astronomical amount of material covered in its text,
all in all, this is a magnificent volume for the connoisseur."
1980, 694 pp.; 331 illus., ISBN 019-520664-9
$115.50 $60.00, APS Member price:
$75.25 $40.00
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Volume IV, Parts 1 & 2
Microcirculation
Edited by Eugene Renkin and C. Charles Michel
Volume IV consolidates the essential concepts and new developments of
microvascular physiology and offers critical assessments of the status of
current ideas and techniques. Chapters cover the structure of the
microcirculation, microvascular growth and adaptation, microcirculatory
dynamics of lymph and blood, material transport, and circulation and
exchange in organ systems.
1984, 1,124 pp.; 631 illus., ISBN 019-520666-5
$288.75 $145.00, APS Member price:
$187.75 $95.00
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Microcirculation
2nd Edition
Edited by Ronald F. Tuma, Walter N. Duran, Klaus Ley
This new volume integrates the subdisciplines and subspecialties of
microcirculation biology. It highlights the explosive growth in knowledge
about the microcirculation including the biology of nitric oxide synthase (NOS),
endothelial cell signaling, angiogenesis, ion channels and receptors. It
covers the essential concepts and new developments of microvascular
physiology and offers critical assessments on the status of current ideas
and techniques.
August 2008, 1,000 pp.; ISBN 978-0-12-374530-9
$199.95, APS Member price: $129.98
To order this book, contact Elsevier Customer Service (phone:
1-800-545-2522). To receive your 35% APS membership discount, please
reference discount code 93575 when ordering.
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Section 3:
The Respiratory System
Section Editor: Alfred P. Fishman
Volume II, Parts 1 & 2
Control of Breathing
Edited by Neil S. Cherniack and John G. Widdicombe
Reflecting today's unprecedented awareness of the interrelationships
among different physiological regulatory systems, this volume encompasses
the diverse topics that must be considered in any study of respiratory
control. Part 1 explores central nervous system control of breathing and the
intimate relationships to afferent inputs and motor pathways. Part 2 reviews
the interplay between respiratory regulation and regulatory mechanisms in
other physiological systems. A separate section reviews the comparative
physiology of respiratory control.
1986, 972 pp.; 385 illus., ISBN 019-520668-1
$257.25 $130.00, APS Member price:
$167.25 $85.00
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Volume III, Parts 1 & 2
Mechanics of Breathing
Edited by Peter T. Macklem and Jere Mead
The contributors to Mechanics of Breathing approach this complex
physiological subject from the perspective of every relevant field:
medicine, anatomy, physiology, engineering, acoustics, physics, mathematics,
surface chemistry, immunology, cellular biology, neurophysiology, and
psychology. Fundamental information about respiratory mechanics makes this a
useful reference on a rapidly evolving subject.
Chest states, "It is by any criteria of critical scrutiny a highly
commendable text and one which is likely to remain the standard of
excellence in the field for a long time to come."
1986, 834 pp.; 407 illus., ISBN 019-520669-X
$257.25 $130.00, APS Member price:
$167.25 $85.00
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Volume IV
Gas Exchange
Edited by Leon E. Farhi and S. Marsh Tenney
Volume IV blends theoretical understanding with recent experimental data
to describe the process of gas exchange. This volume serves as a guide to
new concepts, techniques and directions for future development in studies of
normal and impaired pulmonary gas exchange.
Progress in Respiration Research states that this volume "...will
serve as a guide to new concepts, techniques, and directions of future
development in studies of normal and impaired pulmonary gas exchange."
1987, 480 pp.; 201 illus., ISBN 019-520670-3
$173.25 $85.00, APS Member price:
$112.75 $55.00
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Section 4:
Environmental Physiology
Edited by Melvin J. Fregly and Clark M. Blatteis
(Two-Volume Set)
"An excellent addition to the environmental section of the...series....
This book belongs in all biomedical libraries, general university libraries,
and on the shelf of researchers who study the effects of environmental
factors on mammalian systems. Rating: Four Stars." --Doody's Health
Sciences Review Journal.
Thirty years have passed since the last edition of this volume was
published. Since then, many advances have occurred in the field of
environmental physiology. This volume incorporates all of these advances to
provide the most up-to-date understanding of, and debate over, the
physiological adaptation to the environment.
1996, 2 vol., 1,626 pp.; 464 illus., ISBN 019-507492-0
$309.75 $155.00, APS Member price:
$201.50 $100.00
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Section 6:
The Gastrointestinal System
Section Editor: Stanley G. Schultz
Volume I, Parts 1 & 2
Motility and Circulation
Edited by Jackie D. Wood and Stanley G. Schultz
This new edition documents the advances in methods, understanding of
motility, and vast amounts of information since the publication of the first
volume on gastrointestinal motility in the 1968 Handbook of Physiology.
Progress in understanding the vascular system and lymphatic of the
alimentary canal is reviewed in detail. This book provides an unparalleled
view of gastrointestinal motor and circulatory function. It will be of great
use to a wide spectrum of readers, including physiologists,
gastroenterologists, graduate students, and postdoctoral fellows.
1989, 1,906 pp.; 840 illus., ISBN 019-520791-2
$309.75 $155.00, APS Member price:
$201.50 $100.00
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Volume II
Neural and Endocrine Biology
Edited by Gabriel M. Makhlouf and Stanley G. Schultz
This is the first volume in the Handbook of Physiology to be
devoted entirely to the field of neural and endocrine biology. It is also
the very first volume ever published that deals systematically with the
biochemistry, cell biology, molecular biology, pharmacology, and physiology
of hormonal and neural peptides of the gut. Written by some 40 recognized
experts, Neural and Endocrine Biology will be a welcome new resource
for graduate students, instructors, and active researchers and clinicians
who need a complete up-to-date reference in regulatory peptides and
gastrointestinal physiology and pharmacology.
1989, 736 pp.; 365 illus., ISBN 019-520795-5
$204.75 $100.00, APS Member price:
$133.25 $65.00
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Volume III
Salivary, Gastric, Pancreatic,
and Hepatobiliary Secretion
Edited by John G. Forte and Stanley G. Schultz
The third volume in The Gastrointestinal System reflects the
expansion of knowledge of the cell physiology of secretion. Each chapter,
grouped by traditional anatomical location, emphasizes the cellular bases of
secretion and includes a review of the broader as well as the more
integrative aspects of secretion.
1989, 788 pp.; 365 illus., ISBN 019-520816-1
$204.75 $100.00, APS Member price:
$133.25 $65.00
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Volume IV
Intestinal Absorption and Secretion
Edited by Stanley G. Schultz, Michael Field,
and Raymond A. Frizzell
This volume is a thorough, up-to-date survey of the physiological
processes through which salt, water, and nutrients are absorbed or secreted
by the intestinal tract, and of how these myriad processes are regulated.
Four main topics are covered in 25 chapters written by leading experts: the
methodologies and basic principles of structure and function; intestinal ion
transport; nutrient absorption; and macromolecular transport.
This is the broadest, most contemporary approach to this important topic. As
such, this book will be warmly welcomed and often consulted by students,
scholars, professionals, and anyone researching intestinal absorptive
mechanisms and their regulation.
1991, 672 pp.; 266 illus., ISBN 019-520817-X
$204.75 $100.00, APS Member price:
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Section 7:
The Endocrine System
Volume I
Cellular Endocrinology
Edited by P. Michael Conn
With the many new techniques available in cellular and molecular biology,
it has been possible to identify common patterns of activity in cells of the
endocrine system. This volume provides an in-depth and up-to-date view of
progress in cellular and molecular endocrinology. It deals with the
conceptual fundamentals of receptor identification and structure, gene
expression, signaling, and second messenger systems. It also describes newly
appreciated concepts of receptor and gene regulation, and covers
physiological processes such as secretion, steroidogenesis, and apoptosis.
The chapters are written by international authorities who are well
recognized for their contributions to the field of endocrinology. Combining
physiology and molecular biology, the book will be of value to all basic
endocrinologists and to clinicians interested in the underlying regulation
of endocrine systems.
1998, 616 pp.; 131 illus., ISBN 019-510935-X
$173.25 $85.00, APS Member price:
$112.75 $55.00
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Volume II
The Endocrine Pancreas
and Regulation of Metabolism
Edited by L. S. Jefferson and A. Cherrington
This reference work provides a comprehensive and up-to-date review of
hormonal regulation of metabolism. It is divided into four sections,
following a general introduction by Sir Philip Randle: 1) the islets
of Langerhans, 2) target tissues for metabolic regulatory hormones,
3) influence of hormones acting as acute metabolic regulators on the
actions of islet hormones, and 4) integrated hormonal responses to
physiological challenges. The fourth part covers many interesting conditions
such as pregnancy, aging, obesity, hypoglycemia, insulin-dependent diabetes
mellitus, and starvation.
2000, 600 pp.; 336 illus., ISBN 019-511326-8
$295.00 $150.00, APS Member price:
$191.75 $95.00
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Volume III
Endocrine Regulation of Water
and Electrolyte Balance
Edited by John C.S. Fray
This volume takes an integrative approach to the physiological process of
water and electrolyte balance. It is divided into three parts: sodium and
potassium balance, hormones regulating electrolyte balance, and endocrine
regulation of calcium and phosphate balance. Renin, angiotensinogen,
angiotensin converting enzymes, angiotensins, aldosterone, kallikrein-kinin,
natriuretic hormones, antidiuretic hormone, parathyroid hormone and
polyhormones, parathyroid hormone-related peptide, and vitamin D are
discussed in critical and comprehensive detail. The book presents the
genomic alterations in electrolyte and water balance as functional processes
and thereby helps lay the foundation for the emerging era of functional
genomics in both health and disease.
1999, 736 pp.; 151 illus., ISBN 019-511047-7
$236.25 $120.00, APS Member price:
$153.75 $75.00
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Volume IV
Coping with the Environment: Neural and Endocrine Mechanisms
Edited by Bruce S. McEwen
This volume gives a unique view of the neurobiology of stress and coping
and of the two-way interaction between the environment and the nervous
system. Beginning with the two main stress-mediating systems, the
catecholamines and the hypothalamic-pituitary-adrenal axis, it covers the
neural basis of fear and stress, diurnal rhythms, sleep, immune defense
mechanisms, and stress and coping in the social environment. It is an
indispensable reference for anyone interested in behavioral neuroscience or
endocrinology.
- 2001, 225 pp.; 101 illus., ISBN 019-511252-0
$150.00
$75.00, APS Member price: $97.50
$50.00- Ordering information is available from
APS Customer Service.
-
Volume V
Hormonal Control of Growth
Edited by Jack L. Kostyo
This original book will give a comprehensive picture of the endocrine
regulation of growth. The emphasis will be on growth hormone - its
structure, genetics, secretion, receptors, and actions. Insulin and
insulin-like growth factors and thyroid hormones will also be covered.
1999, 856 pp., 199 illus., ISBN 019-511305-5
$188.50 $95.00, APS Member price:
$122.50 $60.00
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Section 8
Renal Physiology
Edited by Erich E. Windhager
(Two-Volume Set)
These two volumes offer the most up-to-date, comprehensive and
authoritative coverage of kidney function available. Ninety international
authorities present modern concepts of renal function, including the
biochemistry, cell biology, and morphology of the kidney. Experimental
techniques to study renal function are treated in detail. The chapters span
the entire range of knowledge about kidney function, from the level of
plasma membrane to whole organ function, regulation and integration of
kidney function into whole body homeostasis.
1992, 2,544 pp.; 980 illus., ISBN 019-506006-7
$414.75 $205.00, APS Member price:
$269.75 $135.00
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Section 9
Reactions to
Environmental Agents
Edited by Douglas H. K. Lee, Hans L. Falk,
and Sheldon D. Murphy
This text emphasizes well-known environmental perturbations, particularly
those introduced by physical and chemical agents. It will be of interest to
a wide variety of scientists working in industry, engineering, food science,
and the laboratory. Among the topics examined are: response to physical
agents; nature, origin, and distribution of chemical agents; reactions and
determinants at portal entry; transportation and transformation of chemical
agents; distribution and excretion of chemical agents; and mechanisms of
cellular injury.
"Serves as an excellent tool for occupational and environmental health
scientists involved in the task of defining and identifying the potential
risks associated with new environmental and occupational hazards. I would
also encourage its use as a text or at least reference material for courses
in physiology." - Environmental International
1977, 667 pp.; 234 illus., ISBN 019-520684-3
$105.00 $50.00, APS Member price:
$68.25 $35.00
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Section 10
Skeletal Muscle
Edited by Lee D. Peachey
Associate Editor: Richard H. Adrian
In this integrated view of research and possible future developments in
muscle research, an authoritative group of contributors discusses structure,
contraction, excitation-contraction coupling, specialization, adaptation,
and disease. Muscle research is charted from the molecular and cellular
level to that of the whole organism.
1983, 700 pp.; 333 illus., ISBN 019-520685-1
$152.25 $75.00, APS Member price:
$99.00 $50.00
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Section 11
Aging
Edited by Edward J. Masoro
"It is far more than an encyclopedia of senescence in traditionally
defined physiological systems. It is also a comprehensive manual for the
critical design and evaluation of research in a discipline with unique and
often subtle pitfalls... . New researchers, students and educators should
find this book excellent both as an introduction to the current state of
knowledge in the field and as a guide for the evaluation of current theory
and new research." - Experimental Gerontology.
This volume presents comprehensive information on the physiology of aging
targeted to physiologists, gerontologists, and other professionals in the
fields of medicine and biology. The principles of biological gerontology are
discussed at the molecular, cellular and metabolic level, and methodological
issues are explored in depth. Comprehensive coverage of the physiology of
aging of organ systems and organisms is provided, and possible interventions
are considered.
1995, 696 pp.; 152 illus., ISBN 019-507722-9
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Section 12
Exercise: Regulation and
Integration of Multiple Systems
Edited by Loring B. Rowell and John T. Shepherd
This volume deals exclusively with exercise. It is also the first single
volume to analyze, in depth, the regulation and integration of motor,
respiratory, cardiovascular, and metabolic systems over the broad range of
functions demanded by exercise. Its systematic examination of the regulation
of these four systems draws from every area of physiology as well as from
pharmacology, biochemistry, cellular and molecular biology, and medicine. It
highlights exercise as a uniquely powerful means of exploring the
integrative aspects of whole body functions.
1996, 1,224 pp.; 418 illus., ISBN 019-509174-4
$204.75 $100.00, APS Member price:
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Section 13
Comparative Physiology
Edited by William H. Dantzler
(Two-Volume Set)
This Handbook of comparative physiology brings together for the
first time a review of the entire field at the advanced level appropriate
for research scientists, graduate students, postdoctoral fellows, and
faculty. It begins with a chapter on adaptation and the evolution of
physiological characters. After that introduction, it is organized to
provide a complete survey of comparative physiology for both vertebrates and
invertebrates, with up-to-date chapters on each of the organ systems.
Following these chapters, the book addresses comparative physiological
strategies for dealing with many environmental problems such as extreme
temperatures, extreme dryness, seasonal and diurnal cycles, and variations
in salinity and osmolarity of aqueous environments. Thus the book provides a
comprehensive review of the differing physiological strategies employed by
vertebrates and invertebrate species to deal with common problems.
1997, 2 Vol., 1,856 pp.; 629 illus., ISBN 019-507419-X
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Section 14
Cell Physiology
Edited by Joseph F. Hoffman and James D. Jamieson
The aim of this Handbook is to survey key areas in modern cellular
and molecular physiology. The topics covered range from the most fundamental
biophysical and biochemical bases of cellular physiology to more concerted
cellular biological processes. A more elusive goal of this volume is to
provide a framework for future research linking these various processes in
whole animal systems. Researchers, instructors, postdoctorates, and graduate
students will find this a uniquely useful resource.
1997, 982 pp.; 328 illus., ISBN 019-507172-7
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To Order a Handbook
Information for ordering a specific book(s) is available from
APS Customer Service.
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Out-of-Print Handbooks
Out-of-print handbooks and monographs published by the Society are
available in reproduced form from National Archive Publishing Company (www.napubco.com). Please supply ISBN number
when ordering.
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